不同晶相结构ZrO2负载铜基催化剂用于二乙醇胺脱氢反应

通过制备不同晶相结构〔单斜相(m-ZrO_2)、四方相(t-ZrO_2)和无定型(a-ZrO_2)〕ZrO_2载体,再通过沉积沉淀法制得Cu/m-ZrO_2、Cu/t-ZrO_2和Cu/a-ZrO_2催化剂,分别用于催化二乙醇胺脱氢合成亚氨基二乙酸反应。采用XRD、氮气物理吸附脱附、XPS、H_2-TPR、CO_2-TPD对催化剂的结构进行了表征。结果表明,Cu/m-ZrO_2催化剂界面更加有利于Cu~+/Cu~0稳定存在,具有更多的碱性位点,且抗氧化性较好。在二乙醇胺脱氢反应中,Cu/m-ZrO_2催化剂性能最好,反应时间为2.5 h,亚氨基二乙酸收率为97.64%。     

超低渗油藏在线分流酸化增注技术研究与应用

酸化是超低渗油藏最有效的增注措施之一，但由于储层物性差、非均质性强等问题，造成目前常规酸化措施普遍具有施工周期长、有效率低、有效作用距离短等不足，且酸化过程中存在指进现象和储层二次伤害。针对这一问题，选取鄂尔多斯盆地环江油田三叠系超低渗油藏为研究对象，提出了在线分流酸化技术，并配套研制了一种多元缓速螯合酸COA-1S和一种新型的水溶性分流剂COA-1P。通过室内评价实验和在线分流酸化模拟实验，发现该技术在缓速性、配伍性、水溶性、螯合能力和暂堵功能等方面均显著优于常规酸化；现场先导性实验结果表明，酸化后剖面吸水均匀程度从28.5%上升至50.9%，视吸水指数增加2倍左右，降压增注效果显著；同时，该技术还具有“不停井、不泄压、不动管柱、不返排”的特点，简化了常规分流酸化工序、降低了安全环保风险，是一种能够很好地适应超低渗油藏特征的酸化增注技术。     

Poly(L-lysine)-poly(ethylene glycol) layers with different structure and their influence on silica suspension stability

The effects of the structure of di- and triblock copolymers of poly(L-lysine) – LYS with poly(ethylene glycol) – PEG as well as the length of nonionic fragment in the LYS-PEG macromolecule on the copolymer chains conformation in the adsorption layer formed on the colloidal silica (SiO2) surface were examined. Spectrophotometry and turbidimetry were applied for the determination of copolymer adsorbed amounts and stability coefficients of silica aqueous suspensions. The electrokinetic parameters such as solid surface charge density and zeta potential were also estimated. The adsorption of LYS-PEG was proved to be the highest at pH 10 whereas the lowest adsorption on the solid surface was found for the triblock copolymer with long fragments of LYS at the same pH value.     

Covalent Linkage of an R-ω-Transaminase to a d-Amino Acid Oxidase through Protein Splicing to Enhance Enzymatic Catalysis of Transamination

R-ω-Transaminases (RTAs) catalyse the conversion of R-configured amines [e.g., (R)-1-phenylethylamine] into the corresponding ketones (e.g., acetophenone), by transferring an amino group from an amino donor [e.g., (R)-1-phenylethylamine] onto an amino acceptor (e.g., pyruvate), resulting in a co-product (e.g., d -alanine). d -Alanine can be deaminated back to pyruvate by d -amino acid oxidase (DAAOs). Here, through in vivo subunit splicing, the N terminus of an RTA subunit (RTA^S) was specifically ligated to the C terminus of a DAAO subunit (DAAO^S) through native peptide bonds (RTA&DAAO). RTA^S is in close proximity to DAAO^S, at a molecular-scale distance. Thus the transfer of pyruvate and d -alanine between RTA and DAAO can be directional and efficient. Pyruvate→d -alanine→pyruvate cycles are efficiently formed, thus promoting the forward transamination reaction. In a different, in vitro noncovalent approach, based on coiled-coil association, the RTA^S N terminus was specifically associated with the DAAO^S C terminus (RTA#DAAO). In addition, the two mixed individual enzymes (RTA+DAAO) were also studied. RTA&DAAO has a shorter distance between the paired subunits (RTA^S–DAAO^S) than RTA#DAAO, and the number of the paired subunits is higher than in the case of RTA#DAAO, whereas RTA+DAAO cannot form the paired subunits. RTA&DAAO exhibited a transamination catalysis efficiency higher than that of RTA#DAAO and much higher than that of RTA+DAAO.     

Synthesis of the Antibiotic Precursor Thiazolyl‐7‐Aminocephalosporanic Acid in a Microstructured Flow System

The synthesis of thiazolyl‐7‐aminocephalosporanic acid, a pharmaceutical precursor of the β‐lactam antibiotic drug cefodizime, could be successfully realized in a continuous microstructured flow system. This was accomplished by changing the process window from batch, having a reaction temperature of 60 °C with a reaction time of 1 h, to a flow system at temperatures > 100 °C and reaction times of several minutes. The space‐time yield could be increased by a factor of 130.     

硫磷混合酸溶样重铬酸钾容量法测定全铁

介绍了硫磷混合酸溶样重铬酸钾容量法测定矿石中铁含量的方法和步骤。重点讨论了一线生产中的质量控制。     

硫酸体系中锰钽铌矿加压浸出研究

针对单一硫酸体系锰钽铌矿加压浸出下钽铌浸出率均不到10%的问题,在硫酸体系引入助浸剂,考察氟化铵、双氧水、反应压强、硫酸浓度、反应温度、氟化铵矿比对锰钽铌矿加压浸出的影响,采用XRD对浸渣进行物相表征。实验结果表明,在锰钽铌矿加压浸出中,引入助浸剂氟化铵,温度200℃、硫酸浓度50%及氟化铵/矿比为0.8∶1的条件下钽浸出率超过93%,铌浸出率超过96%。引入氟化铵对硫酸体系下锰钽铌矿的加压浸出效果的提升十分显著。